N-Acetylcysteine ameliorates lithium-induced renal failure in rats

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N-Acetylcysteine ameliorates lithium-induced renal failure in rats.

BACKGROUND Prolonged lithium treatment may induce progressive deterioration of renal function in humans and experimental animals. N-Acetylcysteine (NAC) has been shown to be effective in the prevention of hypoperfusion and toxin-induced renal failure, but its effect on lithium nephrotoxicity has not been evaluated yet. The purpose of this study was to examine a possible renoprotective effect of...

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N-acetylcysteine and deferrioxamine protects against acute renal failure induced by ischemia/reperfusion in rats.

OBJECTIVE Antioxidants are widely used in animal models to prevent renal injury after ischemia/reperfusion, but it is unknown if the benefits of antioxidants are additive. In this study, we aimed to investigate the protective effects of N-acetylcysteine plus deferoxamine in an animal model of kidney ischemia/reperfusion injury. METHODS Bilateral kidney ischemia was mastintained for 45 minutes...

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N-acetylcysteine and deferoxamine protect against acute renal failure induced by ischemia/ reperfusion in rats

Renal ischemia is observed in a variety of clinical situations, such as cardiac arrest with recovery, liver and kidney transplantation and partial nephrectomy. The acute renal failure (ARF) observed after ischemia is characterized by a decreased glomerular filtration rate, tubular necrosis and increased renal vascular resistance.(1,2) The ischemia/reperfusion process (I/R) involves multiple pat...

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N-acetylcysteine ameliorates contrast-induced kidney injury in rats with unilateral hydronephrosis

The aim of the present study was to investigate the protective effects of N‑acetylcysteine (NAC) on contrast‑induced acute kidney injury in rats with unilateral hyronephrosis. Eighty‑two male Sprague Dawley rats were randomized to undergo sham operation (n=14) or unilateral ureteral obstruction (UUO) (n=68). After 3 weeks, the UUO animals were randomized to three groups: NAC gastric perfusion, ...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 2004

ISSN: 0931-0509,1460-2385

DOI: 10.1093/ndt/gfh573